Popular acid reflux medication, PPIs, may be linked to a heightened risk of depression, according to a concerning new study published in JAMA Network Open. Researchers analyzed data from over 63,000 individuals and found a significant association between PPI use and depressive disorders.
Proton pump inhibitors (PPIs) – like omeprazole (Prilosec) and lansoprazole (Prevacid) – are widely used to treat heartburn and acid reflux, with over 15 million Americans using them regularly. The study suggests a potential connection, though it doesn't prove PPIs cause depression.
Experts caution that more research is needed to fully understand this link and explore potential mechanisms. This includes investigating how PPIs might affect brain chemistry or gut health, which could influence mood.
If you're experiencing persistent low mood or depression while taking PPIs, discuss your concerns with your doctor. They can evaluate your individual situation and explore alternative treatment options.
